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The role of physical activity in mitigating age-related changes in the neuromuscular control of gait

The role of physical activity in mitigating age-related changes in the neuromuscular control of gait
  • Akima, H. et al. Muscle function in 164 men and women aged 20–84 yr. Med. Sci. Sports Exerc. 33, 220–226 (2001).

    CAS 
    PubMed 

    Google Scholar 

  • Hyatt, R. H., Whitelaw, M. N., Bhat, A., Scott, S. & Maxwell, J. D. Association of muscle strength with functional status of elderly people. Age Ageing 19, 330–336 (1990).

    CAS 
    PubMed 

    Google Scholar 

  • Graça, A. L., Gomez-Florit, M., Gomes, M. E. & Docheva, D. Tendon aging. Subcell. Biochem 103, 121–147 (2023).

    PubMed 

    Google Scholar 

  • Rygiel, K. A., Picard, M. & Turnbull, D. M. The ageing neuromuscular system and sarcopenia: A mitochondrial perspective. J. Physiol. 594, 4499–4512 (2016).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cooper, R., Kuh, D., Hardy, R. & Group, M. R. Objectively measured physical capability levels and mortality: Systematic review and meta-analysis. BMJ 341, c4467 (2010).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Cooper, R. et al. Objective measures of physical capability and subsequent health: a systematic review. Age Ageing 40, 14–23 (2011).

    PubMed 

    Google Scholar 

  • Guralnik, J. M., Ferrucci, L., Simonsick, E. M., Salive, M. E. & Wallace, R. B. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N. Engl. J. Med. 332, 556–561 (1995).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Studenski, S. et al. Gait speed and survival in older adults. JAMA 305, 50–58 (2011).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lexell, J. Human aging, muscle mass, and fiber type composition. J. Gerontol. A Biol. Sci. Med Sci. 50, 11–16 (1995).

    PubMed 

    Google Scholar 

  • Lexell, J., Henriksson-Larsén, K., Winblad, B. & Sjöström, M. Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections. Muscle Nerve 6, 588–595 (1983).

    CAS 
    PubMed 

    Google Scholar 

  • McPhee, J. S. et al. The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia. J. Gerontol. A Biol. Sci. Med Sci. 73, 1287–1294 (2018).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Williamson, D. L., Godard, M. P., Porter, D. A., Costill, D. L. & Trappe, S. W. Progressive resistance training reduces myosin heavy chain coexpression in single muscle fibers from older men. J. Appl. Physiol. 88, 627–633 (2000).

    CAS 
    PubMed 

    Google Scholar 

  • Lexell, J. & Taylor, C. C. Variability in muscle fibre areas in whole human quadriceps muscle: effects of increasing age. J. Anat. 174, 239–249 (1991).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Stenroth, L., Peltonen, J., Cronin, N. J., Sipilä, S. & Finni, T. Age-related differences in Achilles tendon properties and triceps surae muscle architecture in vivo. J. Appl. Physiol. 113, 1537–1544 (2012).

    PubMed 

    Google Scholar 

  • Akagi, R., Yamashita, Y. & Ueyasu, Y. Age-related differences in muscle shear moduli in the lower extremity. Ultrasound Med Biol. 41, 2906–2912 (2015).

    PubMed 

    Google Scholar 

  • Lim, J.-Y., Choi, S. J., Widrick, J. J., Phillips, E. M. & Frontera, W. R. Passive force and viscoelastic properties of single fibers in human aging muscles. Eur. J. Appl. Physiol. 119, 2339–2348 (2019).

    CAS 
    PubMed 

    Google Scholar 

  • Şendur, H. N. et al. Evaluation of effects of aging on skeletal muscle elasticity using shear wave elastography. Eur. J. Radio. 128, 109038 (2020).

    Google Scholar 

  • Çekok, F. K., Taş, S. & Aktaş, A. Muscle and tendon stiffness of lower extremity in older adults with fall history: Stiffness effect on physical performance and fall risk. Geriatr. Nurs. 59, 228–233 (2024).

    PubMed 

    Google Scholar 

  • DeVita, P. & Hortobagyi, T. Age causes a redistribution of joint torques and powers during gait. J. Appl. Physiol. 88, 1804–1811 (2000).

    CAS 
    PubMed 

    Google Scholar 

  • Silder, A., Heiderscheit, B. & Thelen, D. G. Active and passive contributions to joint kinetics during walking in older adults. J. Biomech. 41, 1520–1527 (2008).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Winter, D. A., Patla, A. E., Frank, J. S. & Walt, S. E. Biomechanical walking pattern changes in the fit and healthy elderly. Phys. Ther. 70, 340–347 (1990).

    CAS 
    PubMed 

    Google Scholar 

  • Kerrigan, D. C., Riley, P. O., Rogan, S. & Burke, D. T. Compensatory advantages of toe walking. Arch. Phys. Med Rehabil. 81, 38–44 (2000).

    CAS 
    PubMed 

    Google Scholar 

  • McGibbon, C. A. Toward a better understanding of gait changes with age and disablement: Neuromuscular adaptation. Exerc Sport Sci. Rev. 31, 102–108 (2003).

    PubMed 

    Google Scholar 

  • Franz, J. R. & Kram, R. Advanced age affects the individual leg mechanics of level, uphill, and downhill walking. J. Biomech. 46, 535–540 (2013).

    PubMed 

    Google Scholar 

  • Franz, J. R. The age-associated reduction in propulsive power generation in walking. Exerc Sport Sci. Rev. 44, 129–136 (2016).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Gueugnon, M. et al. Age-related adaptations of lower limb intersegmental coordination during walking. Front Bioeng. Biotechnol. 7, 173 (2019).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Delabastita, T. et al. Distal-to-proximal joint mechanics redistribution is a main contributor to reduced walking economy in older adults. Scand. J. Med. Sci. Sports (2021).

    Article 
    PubMed 

    Google Scholar 

  • Boyer, K. A. et al. Age-related changes in gait biomechanics and their impact on the metabolic cost of walking: Report from a National Institute on Aging workshop. Exp. Gerontol. 173, 112102 (2023).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Marcucci, L. & Reggiani, C. Increase of resting muscle stiffness, a less considered component of age-related skeletal muscle impairment. Eur. J. Transl. Myol. 30, 8982 (2020).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Aagaard, P., Suetta, C., Caserotti, P., Magnusson, S. P. & Kjaer, M. Role of the nervous system in sarcopenia and muscle atrophy with aging: strength training as a countermeasure. Scand. J. Med Sci. Sports 20, 49–64 (2010).

    CAS 
    PubMed 

    Google Scholar 

  • Hunter, S. K., Pereira, H. M. & Keenan, K. G. The aging neuromuscular system and motor performance. J. Appl Physiol. (1985) 121, 982–995 (2016).

    CAS 
    PubMed 

    Google Scholar 

  • Hassan, A. S. et al. Estimates of persistent inward currents are reduced in upper limb motor units of older adults. J. Physiol. 599, 4865–4882 (2021).

    CAS 
    PubMed 

    Google Scholar 

  • Orssatto, L. B. R. et al. Do motoneuron discharge rates slow with aging? A systematic review and meta-analysis. Mech. Ageing Dev. 203, 111647 (2022).

    PubMed 

    Google Scholar 

  • Dewolf, A. H., Sylos-Labini, F., Cappellini, G., Ivanenko, Y. & Lacquaniti, F. Age-related changes in the neuromuscular control of forward and backward locomotion. PLOS ONE 16, e0246372 (2021).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Dewolf, A. H. et al. Neuromuscular age-related adjustment of gait when moving upwards and downwards. Front Hum. Neurosci. 15, 749366 (2021).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Nùñez-Lisboa, M., Valero-Breton, M. & Dewolf, A. H. Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives. Front Physiol. 14, 1194889 (2023).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kraemer, W. J. et al. Progression models in resistance training for healthy adults. Med. Sci. Sports Exerc. 34, 364–380 (2002).

    PubMed 

    Google Scholar 

  • da Cunha, J., Maselli, L. M. F., Stern, A. C. B., Spada, C. & Bydlowski, S. P. Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs. World J. Virol. 4, 56–77 (2015).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Pour, M.-A. B., Joukar, S., Hovanloo, F. & Najafipour, H. Long-term low-intensity endurance exercise along with blood-flow restriction improves muscle mass and neuromuscular junction compartments in old rats. Iran. J. Med Sci. 42, 569–576 (2017).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen, N., He, X., Feng, Y., Ainsworth, B. E. & Liu, Y. Effects of resistance training in healthy older people with sarcopenia: a systematic review and meta-analysis of randomized controlled trials. Eur. Rev. Aging Phys. Act. 18, 1–19 (2021).

    CAS 

    Google Scholar 

  • el Hadouchi, M., Kiers, H., de Vries, R., Veenhof, C. & van Dieën, J. Effectiveness of power training compared to strength training in older adults: a systematic review and meta-analysis. Eur. Rev. Aging Phys. Act. 19, 1–15 (2022).

    Google Scholar 

  • Markov, A., Hauser, L. & Chaabene, H. Effects of concurrent strength and endurance training on measures of physical fitness in healthy middle-aged and older adults: a systematic review with meta-analysis. Sports Med. 53, 437–455 (2022).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Reid, K. F. & Fielding, R. A. Skeletal muscle power: A critical determinant of physical functioning in older adults. Exerc Sport Sci. Rev. 40, 4–12 (2012).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Cogliati, M. et al. Half marathon induces changes in central control and peripheral properties of individual motor units in master athletes. J. Electromyogr. Kinesiol. 55, 102472 (2020).

    PubMed 

    Google Scholar 

  • Rogers, R. S. & Nishimune, H. The Role of Laminins in the organization and function of Neuromuscular junctions. Matrix Biol. 57–58, 86–105 (2017).

    PubMed 

    Google Scholar 

  • Wang, Q. et al. Effects of physical exercise on neuromuscular junction degeneration during ageing: A systematic review. J. Orthop. Transl. 46, 91–102 (2024).

    Google Scholar 

  • Harridge, S. D., Kryger, A. & Stensgaard, A. Knee extensor strength, activation, and size in very elderly people following strength training. Muscle Nerve 22, 831–839 (1999).

    CAS 
    PubMed 

    Google Scholar 

  • Beijersbergen, C. M. I., Granacher, U., Vandervoort, A. A., DeVita, P. & Hortobágyi, T. The biomechanical mechanism of how strength and power training improves walking speed in old adults remains unknown. Ageing Res. Rev. 12, 618–627 (2013).

    CAS 
    PubMed 

    Google Scholar 

  • Boyer, K. A., Andriacchi, T. P. & Beaupre, G. S. The role of physical activity in changes in walking mechanics with age. Gait Posture 36, 149–153 (2012).

    PubMed 

    Google Scholar 

  • Cavagna, G. A., Thys, H. & Zamboni, A. The sources of external work in level walking and running. J. Physiol. (Lond.) 262, 639–657 (1976).

    CAS 
    PubMed 

    Google Scholar 

  • Dewolf, A. H., Ivanenko, Y. P., Zelik, K. E., Lacquaniti, F. & Willems, P. A. Differential activation of lumbar and sacral motor pools during walking at different speeds and slopes. J. Neurophysiol. 122, 872–887 (2019).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Das Gupta, S., Bobbert, M. F. & Kistemaker, D. A. The metabolic cost of walking in healthy young and older adults – A systematic review and meta analysis. Sci. Rep. 9, 9956 (2019).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Aboutorabi, A., Arazpour, M., Bahramizadeh, M., Hutchins, S. W. & Fadayevatan, R. The effect of aging on gait parameters in able-bodied older subjects: a literature review. Aging Clin. Exp. Res. 28, 393–405 (2016).

    PubMed 

    Google Scholar 

  • Mian, O. S., Thom, J. M., Ardigò, L. P., Narici, M. V. & Minetti, A. E. Metabolic cost, mechanical work, and efficiency during walking in young and older men. Acta Physiol. 186, 127–139 (2006).

    CAS 

    Google Scholar 

  • Ortega, J. D. & Farley, C. T. Individual limb work does not explain the greater metabolic cost of walking in elderly adults. J. Appl. Physiol. 102, 2266–2273 (2007).

    PubMed 

    Google Scholar 

  • Dewolf, A. H. et al. Relation between step-to-step transition strategies and walking pattern in older adults. Appl. Sci. 12, 5055 (2022).

    CAS 

    Google Scholar 

  • Meurisse, G. M., Bastien, G. J. & Schepens, B. Effect of age and speed on the step-to-step transition phase during walking. J. Biomech. 83, 253–259 (2019).

    PubMed 

    Google Scholar 

  • Lay, A. N., Hass, C. J. & Gregor, R. J. The effects of sloped surfaces on locomotion: A kinematic and kinetic analysis. J. Biomech. 39, 1621–1628 (2006).

    PubMed 

    Google Scholar 

  • Monaco, V. & Micera, S. Age-related neuromuscular adaptation does not affect the mechanical efficiency of lower limbs during walking. Gait Posture 36, 350–355 (2012).

    CAS 
    PubMed 

    Google Scholar 

  • Núñez-Lisboa, M. et al. Understanding gait alterations: trunk flexion and its effects on walking neuromechanics. J. Exp. Biol. 227, jeb249307 (2024).

    PubMed 

    Google Scholar 

  • Cavagna, G. A. & Kaneko, M. Mechanical work and efficiency in level walking and running. J. Physiol. 268, 467–481 (1977).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Full, R. J. & Koditschek, D. E. Templates and anchors: neuromechanical hypotheses of legged locomotion on land. J. Exp. Biol. 202, 3325–3332 (1999).

    CAS 
    PubMed 

    Google Scholar 

  • Usherwood, J. R., Channon, A. J., Myatt, J. P., Rankin, J. W. & Hubel, T. Y. The human foot and heel-sole-toe walking strategy: A mechanism enabling an inverted pendular gait with low isometric muscle force? J. R. Soc. Interface 9, 2396–2402 (2012).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mesquita, R. M., Catavitello, G., Willems, P. A. & Dewolf, A. H. Modification of the locomotor pattern when deviating from the characteristic heel-to-toe rolling pattern during walking. Eur. J. Appl Physiol. (2023).

    Article 
    PubMed 

    Google Scholar 

  • Peterson, D. S. & Martin, P. E. Effects of age and walking speed on coactivation and cost of walking in healthy adults. Gait Posture 31, 355–359 (2010).

    PubMed 

    Google Scholar 

  • Hortobágyi, T., Finch, A., Solnik, S., Rider, P. & DeVita, P. Association between muscle activation and metabolic cost of walking in young and old adults. J. Gerontol. Ser. A, Biol. Sci. Med. Sci. 66, 541–547 (2011).

    Google Scholar 

  • VanSwearingen, J. M. & Studenski, S. A. Aging, Motor Skill, and the Energy Cost of Walking: Implications for the Prevention and Treatment of Mobility Decline in Older Persons. J. Gerontol. A Biol. Sci. Med Sci. 69, 1429–1436 (2014).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Schmitz, A., Silder, A., Heiderscheit, B., Mahoney, J. & Thelen, D. G. Differences in lower-extremity muscular activation during walking between healthy older and young adults. J. Electromyogr. Kinesiol 19, 1085–1091 (2009).

    PubMed 

    Google Scholar 

  • Marques, N. R. et al. Association between energy cost of walking, muscle activation, and biomechanical parameters in older female fallers and non-fallers. Clin. Biomech. 28, 330–336 (2013).

    Google Scholar 

  • Delmonico, M. J., Harris, T. B., Visser, M., Park, S. W., Conroy, M. B. & Velasquez-Mieyer, P. et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 90, 1579–85 (2009).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Goodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M. & Schwartz, A. V. et al. The loss of skeletal muscle strength, mass, and quality in older adults: the Health, Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci 61, 1059–64 (2006).

    PubMed 

    Google Scholar 

  • Bhargava, L. J., Pandy, M. G. & Anderson, F. C. A phenomenological model for estimating metabolic energy consumptionin muscle contraction. J Biomech. 37, 81–8 (2004).

    PubMed 

    Google Scholar 

  • Monaco, V., Ghionzoli, A. & Micera, S. Age-related modifications of muscle synergies and spinal cord activity during locomotion. J. Neurophysiol. 104, 2092–2102 (2010).

    PubMed 

    Google Scholar 

  • Avaltroni, P., Cappellini, G., Sylos-Labini, F., Ivanenko, Y. & Lacquaniti, F. Spinal maps of motoneuron activity during human locomotion: neuromechanical considerations. Front. Physiol. 15, 1389436 (2024).

  • Horak, F. B. Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Age Ageing 35, ii7–ii11 (2006). Suppl 2.

    PubMed 

    Google Scholar 

  • Meurisse, G. M., Bastien, G. J. & Schepens, B. The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults? PLOS ONE 14, e0220791 (2019).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Martino, G. et al. Neuromuscular adjustments of gait associated with unstable conditions. J. Neurophysiol. 114, 2867–2882 (2015).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Santuz, A. et al. Neuromotor Dynamics of Human Locomotion in Challenging Settings. iScience 23, 100796 (2020).

    PubMed 

    Google Scholar 

  • Wang, Y., Watanabe, K. & Asaka, T. Effect of dance on multi-muscle synergies in older adults: a cross-sectional study. BMC Geriatrics 19, 340 (2019).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Venturelli, M. et al. Effects of endurance, circuit, and relaxing training on cardiovascular risk factors in hypertensive elderly patients. Age 37, 5–19 (2015).

  • Pardes, A. et al. Aging leads to inferior Achilles tendon mechanics and altered ankle function in rodents. J. Biomech. 60, 30–38 (2017).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Song, S. & Geyer, H. Predictive neuromechanical simulations indicate why walking performance declines with ageing. J. Physiol. 596, 1199–1210 (2018).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Beijersbergen, C. M. I., Granacher, U., Gäbler, M., Devita, P. & Hortobágyi, T. Power training-induced increases in muscle activation during gait in old adults. Med. Sci. Sports Exerc. 49, 2198–2205 (2017).

    PubMed 

    Google Scholar 

  • Beck, O. N. et al. Older runners retain youthful running economy despite biomechanical differences. Med. Sci. Sports Exerc. 48, 697–704 (2016).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Karamanidis, K. & Arampatzis, A. Mechanical and morphological properties of different muscle-tendon units in the lower extremity and running mechanics: effect of aging and physical activity. J. Exp. Biol. 208, 3907–3923 (2005).

    PubMed 

    Google Scholar 

  • Gollhofer, A., Strojnik, V., Rapp, W. & Schweizer, L. Behaviour of triceps surae muscle-tendon complex in different jump conditions. Eur. J. Appl. Physiol. Occup. Physiol. 64, 283–291 (1992).

    CAS 
    PubMed 

    Google Scholar 

  • Hortobágyi, T. & DeVita, P. Mechanisms responsible for the age-associated increase in coactivation of antagonist muscles. Exerc. Sport Sci. Rev. 34, 29–35 (2006).

    PubMed 

    Google Scholar 

  • Mortaza, N., Abu Osman, N. A. & Mehdikhani, N. Are the spatio-temporal parameters of gait capable of distinguishing a faller from a non-faller elderly? Eur. J. Phys. Rehabil. Med 50, 677–691 (2014).

    CAS 
    PubMed 

    Google Scholar 

  • Allen, J. L. & Franz, J. R. The motor repertoire of older adult fallers may constrain their response to balance perturbations. J. Neurophysiol. 120, 2368–2378 (2018).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Baş, H. et al. Lower gastrocnemius muscle stiffness, derived from elastography, is an independent factor for falls in older adults. Aging Clin. Exp. Res 35, 2979–2986 (2023).

    PubMed 

    Google Scholar 

  • Tangen, E. M., Gjestvang, C., Stensrud, T. & Haakstad, L. A. H. Is there an association between total physical activity level and VO2max among fitness club members? A cross-sectional study. BMC Sports Sci. Med. Rehab. 14, 109 (2022).

    Google Scholar 

  • Kraus, W. E. et al. Daily step counts for measuring physical activity exposure and its relation to health. Med Sci. Sports Exerc 51, 1206–1212 (2019).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Metcalf, K. M. et al. Calibration of the global physical activity questionnaire to accelerometry measured physical activity and sedentary behavior. BMC Public Health 18, 412 (2018).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Bull, F. C. et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br. J. Sports Med 54, 1451–1462 (2020).

    PubMed 

    Google Scholar 

  • Lee, S. J. & Hidler, J. Biomechanics of overground vs. treadmill walking in healthy individuals. J. Appl Physiol. (1985) 104, 747–755 (2008).

    PubMed 

    Google Scholar 

  • Van Hooren, B. et al. Is motorized treadmill running biomechanically comparable to overground running? a systematic review and meta-analysis of cross-over studies. Sports Med. 50, 785–813 (2020).

    PubMed 

    Google Scholar 

  • Pearson, S. J. et al. Muscle function in elite master weightlifters. Med. Sci. Sports Exerc. 34, 1199–1206 (2002).

    PubMed 

    Google Scholar 

  • Hunter, G. R., Wetzstein, C. J., Fields, D. A., Brown, A. & Bamman, M. M. Resistance training increases total energy expenditure and free-living physical activity in older adults. J. Appl. Physiol. 89, 977–984 (2000).

    CAS 
    PubMed 

    Google Scholar 

  • Valenti, G., Bonomi, A. G. & Westerterp, K. R. Multicomponent fitness training improves walking economy in older adults. Med. Sci. Sports Exerc. 48, 1365–1370 (2016).

    PubMed 

    Google Scholar 

  • Malatesta, D., Simar, D., Saad, H. B., Préfaut, C. & Caillaud, C. Effect of an overground walking training on gait performance in healthy 65- to 80-year-olds. Exp. Gerontol. 45, 427–434 (2010).

    PubMed 

    Google Scholar 

  • Willems, P. A. & Gosseye, T. P. Does an instrumented treadmill correctly measure the ground reaction forces? Biol. Open 2, 1421–1424 (2013).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Dewolf, A. H., Ivanenko, Y., Zelik, K. E., Lacquaniti, F. & Willems, P. A. Kinematic patterns while walking on a slope at different speeds. J. Appl Physiol. (1985) 125, 642–653 (2018).

    CAS 
    PubMed 

    Google Scholar 

  • Garcia-Bernal, M.-I., Heredia-Rizo, A. M., Gonzalez-Garcia, P., Cortés-Vega, M.-D. & Casuso-Holgado, M. J. Validity and reliability of myotonometry for assessing muscle viscoelastic properties in patients with stroke: a systematic review and meta-analysis. Sci. Rep. 11, 5062 (2021).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Agyapong-Badu, S., Warner, M., Samuel, D. & Stokes, M. Measurement of ageing effects on muscle tone and mechanical properties of rectus femoris and biceps brachii in healthy males and females using a novel hand-held myometric device. Arch. Gerontol. Geriatrics 62, 59–67 (2016).

    Google Scholar 

  • Nguyen, A. P., Verdebout, J., Fontaine, A., Mahaudens, P. & Detrembleur, C. Recommendation for stiffness measurement on gastrocnemii and Achilles tendon at rest and in loaded conditions. Eur. Rehab. J. 4, 1–10 (2024).

    Google Scholar 

  • Dewolf, A. H., Meurisse, G. M., Schepens, B. & Willems, P. A. Effect of walking speed on the intersegmental coordination of lower-limb segments in elderly adults. Gait Posture 70, 156–161 (2019).

    CAS 
    PubMed 

    Google Scholar 

  • Mesquita, R. M. et al. The bouncing mechanism of running against hindering, or with aiding traction forces: a comparison with running on a slope. Eur. J. Appl Physiol. (2020).

    Article 
    PubMed 

    Google Scholar 

  • Nordin, F., Nyberg, A. & Sandberg, C. Concurrent validity of a fixated hand-held dynamometer for measuring isometric knee extension strength in adults with congenital heart disease. Eur. J. Physiother. 22, 206–211 (2020).

    Google Scholar 

  • Dragoi, I. I. et al. Acute effects of sedentary behavior on ankle torque assessed with a custom-made electronic dynamometer. J. Clin. Med. 11, 2474 (2022).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Meurisse, G. M., Dierick, F., Schepens, B. & Bastien, G. J. Determination of the vertical ground reaction forces acting upon individual limbs during healthy and clinical gait. Gait Posture 43, 245–250 (2016).

    PubMed 

    Google Scholar 

  • Dewolf, A. H., Ivanenko, Y. P., Mesquita, R. M. & Willems, P. A. Postural control in the elephant. J. Exp. Biol. 224, jeb243648 (2021).

    PubMed 

    Google Scholar 

  • Dewolf, A. H., Peñailillo, L. E. & Willems, P. A. The rebound of the body during uphill and downhill running at different speeds. J. Exp. Biol. 219, 2276–2288 (2016).

    CAS 
    PubMed 

    Google Scholar 

  • Borghese, N. A., Bianchi, L. & Lacquaniti, F. Kinematic determinants of human locomotion. J. Physiol. 494, 863–879 (1996).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhvansky, D. S. et al. Evaluation of spatiotemporal patterns of the spinal muscle coordination output during walking in the exoskeleton. Sens. (Basel) 22, 5708 (2022).

    Google Scholar 

  • Martino, G. et al. Locomotor patterns in cerebellar ataxia. J. Neurophysiol. 112, 2810–2821 (2014).

    CAS 
    PubMed 

    Google Scholar 

  • Batschelet, E. Circular Statistics in Biology. (Academic Press, 1981).

  • Kendall, F., McCreary, E., Provance, P., Rodgers, M. & Romani, W. Muscles. Testing and Function with Posture and Pain. (Lippincott Williams and Wilkins, Baltimore, 2005).

  • Rudolph, K. S., Axe, M. J. & Snyder-Mackler, L. Dynamic stability after ACL injury: who can hop? Knee Surg. Sports Traumatol. Arthrosc. 8, 262–269 (2000).

    CAS 
    PubMed 

    Google Scholar 

  • Mari, S. et al. Lower limb antagonist muscle co-activation and its relationship with gait parameters in cerebellar ataxia. Cerebellum 13, 226–236 (2014).

    CAS 
    PubMed 

    Google Scholar 

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